March 28, 2026

Retinol VS RetinART

For decades, retinol has defined the anti-ageing category. Effective, but often aggressive—pushing the skin into renewal at the expense of comfort and barrier integrity. Many people abandoned retinol altogether because their skin simply cannot tolerate it - even at low strengths.

Today, a more advanced approach exists. One that delivers superior results, without compromise.

At the centre of this evolution is RetinART®, a next-generation bio-retinoid that delivers outstanding anti-premature ageing and anti-acne results—without the irritation. 

Clinically Proven to perform better 

In a controlled, head-to-head 56-day study, 2% RetinART® was evaluated directly against 0.3% retinol.

The results were decisive. 

Skin Renewal & Brightening:

Texture Improvement: 94% of participants using RetinART saw improved skin texture, compared to 76% using traditional retinol.

Melanin Reduction: A 1% dosage of RetinART achieved a 33% reduction in melanin synthesis, significantly outperforming 0.15% pure retinol (9%) and 1% bakuchiol (21%).

Cell Proliferation: RetinART enhanced cell proliferation by 38%, nearly triple the 15% seen with retinol.                                                

Collagen & Hydration:

Collagen Synthesis: RetinART increased Collagen I by +127% and Collagen III by +176%.

Hyaluronic Acid: It also increased hyaluronic acid levels by +8%, contributing to better hydration than standard retinoids.

Tolerance & Irritation:

Side Effects: While traditional retinol often causes redness, peeling, and dryness, RetinART reported 0% irritation in clinical tests.

Sun Sensitivity: Unlike traditional retinol, RetinART is non-photosensitizing, making it safer for use during daytime use

The results represent a significant biological response - supporting firmer, brighter, more even-toned skin.

Beyond molecular markers, visible outcomes were equally compelling:

  • Greater reduction in wrinkle depth compared to retinol
  • Improved skin firmness and density
  • Faster onset of visible results

Visible Transformation, Faster Results 

In just 14 days, participants using RetinART® observed:

  • Up to 23% improvement in skin elasticity
  • Enhanced radiance and skin luminosity

This accelerated response is critical. It reflects not just efficacy—but efficiency.

Skin is not being forced into renewal. It is being guided.

A Retinol-Like Mechanism—Without the Irritation

RetinART® delivers a retinol-like mechanism of action, activating pathways involved in cellular renewal and collagen synthesis. However, unlike traditional retinol, it is designed for precision and connects with receptor sites on a deeper level resulting in;

  • Reduced irritation
  • Lower incidence of erythema
  • Improved tolerance across skin types

Comparative studies further show:

  • Skin elasticity improvements ranging from ~13% to 23%
  • Significantly improved skin texture and barrier quality versus retinol

Pregnancy safe

Retinol belongs to a class of compounds known as retinoids, all of which are derived from vitamin A. When applied to the skin, retinol undergoes a conversion process:

Retinol → Retinaldehyde → Retinoic Acid

It is the Retinoic Acid that is responsible for skin renewal and collagen regeneration but excessive systemic exposure to retinoids (particularly oral forms like isotretinoin) is known to carry teratogenic risk—meaning it can interfere with fetal development.

While topical retinol is significantly lower risk, the precautionary principle applies:

  • Retinoids can be absorbed through the skin in small amounts
  • They act on cellular signalling pathways involved in growth and differentiation
  • Because of this, most regulatory bodies and clinicians recommend avoiding all vitamin A derivatives during pregnancy

RetinART® is not a vitamin A derivative and is pregnancy safe. It is a marine-derived bio-retinoid, designed to deliver a retinol-like effect without converting into retinoic acid.

Instead of forcing the skin through the traditional retinoid pathway, it works by:

  • Selectively activating retinoid-related receptors (RAR-β)
  • Supporting collagen synthesis and cellular renewal through targeted signalling
  • Avoiding the broad, overstimulating activation seen with retinol

Retinol is not sun safe ☀️

Retinol also has photostability limitations.

  • It degrades when exposed to UV light, reducing its effectiveness
  • It can increase skin photosensitivity, making skin more prone to irritation and sun damage
  • Combined, this is why retinol is generally recommended for night-time use only, with strict daily SPF

RetinART is sun safe and photostable, meaning it can be used both morning and night. This allows for:

  • Continuous collagen support
  • Consistent daily use
  • Faster visible results without cycling or downtime

Faster results. Greater performance. Zero compromise. 

Bio Retinol Crème a better choice 


With RetinART you no longer need to choose between effective, active skincare that gets results and protecting your precious skins barrier function. Our Bio Retinol Creme has been formulated synergistically to activate retinoid-responsive renewal pathways while supporting skin tolerance and barrier integrity. The result is retinol-level refinement without irritation. To reinforce long-term skin health, the crème is fortified with a proprietary ceramide complex and biomimetic lipid blend that restores the skin’s natural lipid architecture while locking in hydration for 72 hours. The advanced longevity peptide Juveleven® targets premature skin ageing at a cellular level, while a synergistic complex of Mountain Pepper Berry, Native River Mint, and Bitter Orange targets inflammaging, which causes the skin to age faster by breaking down important components like collagen, elastin, and hyaluronic acid.